ea0016oc5.4 | Reproduction | ECE2008
Rossetti Raffaella
, Di Pasquale Elisa
, Marozzi Anna
, Bione Silvia
, Beck-Peccoz Paolo
, Persani Luca
BMP15 is an oocyte-derived growth factor belonging to TGF-β superfamily involved in follicular development as a critical regulator of granulosa cell processes. BMP15 gene maps at Xp11.2 and is expressed throughout folliculogenesis. BMP15 is translated as a pre-proprotein consisting of signal peptide, pro-region and mature peptide. The pro-region has an important role in the processing driving the pro-protein dimerization and secretion of active mature dimers. We report th...